ST. LOUIS, MO – October 21, 2026 (STL.News) The Missouri Department of Transportation (MoDOT) is preparing for a major construction project that will shut down a section of eastbound Interstate 64 in St. Louis for approximately one year, creating significant changes for commuters, businesses, residents, and visitors traveling through the city’s Midtown corridor. The planned closure, expected to begin in fall 2027 and continue until fall 2028, will affect eastbound I-64, also known as Highway 40, between Vandeventer Avenue and Compton Avenue. The project involves replacing an aging elevated interstate bridge, redesigning portions of the interchange at Grand
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